FOLLTROPIN-V - Bovine

POTENCY AND PURITY:

It has been previously demonstrated that the ratio of follicle stimulating hormone (FSH) to luteinizing hormone (LH) present in pituitary extracts affects the ability of the ovary to respond to exogenous gonadotropin treatment.1,2,3 Mean ovulation rates have been shown to decrease when the LH:FSH ratio increases.1 Previous FSH preparations have been shown to contain large amounts of LH, and to vary greatly in the LH:FSH ratio.1,3,6 Prior to breeding and the collection of fertilized embryo from these animals, estrus will have to be induced with prostaglandin F2a or a prostaglandin F2a analogue. The purification and quality control procedures used in preparing Folltropin®-V ensures consistently low LH:FSH ratios.(3,6)

INDICATIONS:

For use in reproductively mature heifers or cows to induce a superovulation.

DOSAGE AND ADMINISTRATION:

Reconstitute Folltropin®-V with Folltropin®-V Diluent. Reconstitution and subsequent withdrawal of product should be performed using strict aseptic technique. Start injections on day 8 to 10 following observed or induced estrus. Administer 2.5 mL (50mg*) of Folltropin®-V intramuscularly, twice daily, for 4 days.

Storage:

Store at room temperature (15-30°C). Once reconstituted, Folltropin®-V should be stored at 2-7ºC (36-45ºF) for no longer than 5 days.

Warning(s):

Do not slaughter animals for human consumption for 10 days following the last injection of Folltropin®-V.

Caution:

Do not use this product in swine. In the event of a hypersensitivity reaction, administer epinephrine.

PACKAGING:

20 mL vial of 400 mg*. NIH-FSH-P1 with 20 mL diluent

*Equivalent to National Institutes of Health (USA) Reference Standard NIH-FSH-P1